Transcranial focused ultrasound (FUS) is one of the noninvasive therapeutic modalities where an ultrasound beam is transmitted skull bone to a targeted brain region to locally induce thermal and mechanical effects. We are currently investigating ultrasonic wave propagation through the skull and in-situ monitoring of its effects to have a better understanding of the underlying skull-tissue interaction mechanisms and to establish more comprehensive and safer FUS solutions for tumor treatment and drug delivery through the blood brain barrier.
Project funding: NIH
Associated students: M Sait Kilinc
References
[1] “Kilinc, M.S., Schoen Jr, S.J., Arvanitis, C.D., Degertekin, F.L. “Detailed Numerical and Experimental Investigation of Lamb Wave Mode Conversion for Transcranial Ultrasound Delivery” in 2019 IEEE International Ultrasonics Symposium (Glasgow, UK, Oct. 2019).”